| The serpins are an expanding superfamily of structurally similar but functionally diverse proteins GA Silverman, PI Bird, RW Carrell, FC Church, PB Coughlin, PGW Gettins, ... Journal of Biological Chemistry 276 (36), 33293-33296, 2001 | 1611 | 2001 |
| Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function JA Irving, RN Pike, AM Lesk, JC Whisstock Genome research 10 (12), 1845-1864, 2000 | 778 | 2000 |
| Functional insights from the distribution and role of homopeptide repeat-containing proteins NG Faux, SP Bottomley, AM Lesk, JA Irving, JR Morrison, MG de la Banda, ... Genome research 15 (4), 537-551, 2005 | 236 | 2005 |
| Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous … GA Silverman, JC Whisstock, DJ Askew, SC Pak, CJ Luke, S Cataltepe, ... Cellular and Molecular Life Sciences CMLS 61, 301-325, 2004 | 216 | 2004 |
| Serpins in prokaryotes JA Irving, PJM Steenbakkers, AM Lesk, HJMO den Camp, RN Pike, ... Molecular Biology and Evolution 19 (11), 1881-1890, 2002 | 133 | 2002 |
| The Murine Orthologue of Human Antichymotrypsin A STRUCTURAL PARADIGM FOR CLADE A3 SERPINS AJ Horvath, JA Irving, J Rossjohn, RH Law, SP Bottomley, NS Quinsey, ... Journal of Biological Chemistry 280 (52), 43168-43178, 2005 | 129 | 2005 |
| Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection RHP Law, PM Smooker, JA Irving, D Piedrafita, R Ponting, NJ Kennedy, ... Infection and immunity 71 (12), 6921-6932, 2003 | 122 | 2003 |
| Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering α1-antitrypsin to inhibit cathepsin proteases JA Irving, RN Pike, W Dai, D Brömme, DM Worrall, GA Silverman, ... Biochemistry 41 (15), 4998-5004, 2002 | 109 | 2002 |
| Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis T Welss, J Sun, JA Irving, R Blum, AI Smith, JC Whisstock, RN Pike, ... Biochemistry 42 (24), 7381-7389, 2003 | 107 | 2003 |
| Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation JA Irving, SS Shushanov, RN Pike, EY Popova, D Brömme, THT Coetzer, ... Journal of Biological Chemistry 277 (15), 13192-13201, 2002 | 107 | 2002 |
| Protein structural alignments and functional genomics JA Irving, JC Whisstock, AM Lesk Proteins: Structure, Function, and Bioinformatics 42 (3), 378-382, 2001 | 104 | 2001 |
| The evolution of enzyme specificity in Fasciola spp. JA Irving, TW Spithill, RN Pike, JC Whisstock, PM Smooker Journal of Molecular Evolution 57 (1), 1-15, 2003 | 99 | 2003 |
| The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases M Al-Khunaizi, CJ Luke, YS Askew, SC Pak, DJ Askew, S Cataltepe, ... Biochemistry 41 (9), 3189-3199, 2002 | 89 | 2002 |
| The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix RHP Law, JA Irving, AM Buckle, K Ruzyla, M Buzza, ... Journal of Biological Chemistry 280 (23), 22356-22364, 2005 | 88 | 2005 |
| For the record: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica PM Smooker, JC Whisstock, JA Irving, S Siyaguna, TW Spithill, RN Pike Protein Science 9 (12), 2567-2572, 2000 | 80 | 2000 |
| A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile … SA Beckham, D Piedrafita, CI Phillips, N Samarawickrema, RHP Law, ... The international journal of biochemistry & cell biology 41 (7), 1601-1612, 2009 | 69 | 2009 |
| The 1.5 Å crystal structure of a prokaryote serpin: controlling conformational change in a heated environment JA Irving, LD Cabrita, J Rossjohn, RN Pike, SP Bottomley, JC Whisstock Structure 11 (4), 387-397, 2003 | 64 | 2003 |
| Phosphoproteins in stress-induced disease. LE Dalton, E Healey, J Irving, SJ Marciniak Progress in molecular biology and translational science 106, 189-221, 2012 | 61 | 2012 |
| Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3'proline in facilitating RSL cleavage C Luke, C Schick, C Tsu, JC Whisstock, JA Irving, D Brömme, L Juliano, ... Biochemistry 39 (24), 7081-7091, 2000 | 60 | 2000 |
| A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity A Ordóñez, J Pérez, L Tan, JA Dickens, N Motamedi-Shad, JA Irving, ... The FASEB Journal 29 (6), 2667-2678, 2015 | 58 | 2015 |
James WhisstockMonash University, ARC Centre of Excellence in Advanced Molecular Imaging, EMBL AustraliaVerified email at monash.edu
