Structural analysis of a set of proteins resulting from a bacterial genomics project J Badger, JM Sauder, JM Adams, S Antonysamy, K Bain, MG Bergseid, ... Proteins: Structure, Function, and Bioinformatics 60 (4), 787-796, 2005 | 295 | 2005 |
Haloalkane dehalogenases: structure of a Rhodococcus enzyme J Newman, S Thomas, R Richard, L Kan, PE Swanson, JA Affholter, ... Biochemistry 38 (49), 16105-16114, 1999 | 272 | 1999 |
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth JB Baell, DJ Leaver, SJ Hermans, GL Kelly, MS Brennan, NL Downer, ... Nature 560 (7717), 253-257, 2018 | 243 | 2018 |
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor YL Liang, M Khoshouei, G Deganutti, A Glukhova, C Koole, TS Peat, ... Nature 561 (7724), 492-497, 2018 | 241 | 2018 |
Identification and characterization of two families of F420H2‐dependent reductases from Mycobacteria that catalyse aflatoxin degradation MC Taylor, CJ Jackson, DB Tattersall, N French, TS Peat, J Newman, ... Molecular microbiology 78 (3), 561-575, 2010 | 195 | 2010 |
Structure of the UmuD′ protein and its regulation in response to DNA damage TS Peat, EG Frank, JP McDonald, AS Levine, R Woodgate, ... Nature 380 (6576), 727-730, 1996 | 184 | 1996 |
HBO1 is required for the maintenance of leukaemia stem cells L MacPherson, J Anokye, MM Yeung, EYN Lam, YC Chan, CF Weng, ... Nature 577 (7789), 266-270, 2020 | 146 | 2020 |
Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 Å resolution TS Peat, J Newman, GS Waldo, J Berendzen, TC Terwilliger Structure 6 (9), 1207-1214, 1998 | 146 | 1998 |
A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs HA Lewis, EB Furlong, B Laubert, GA Eroshkina, Y Batiyenko, JM Adams, ... Structure 9 (6), 527-537, 2001 | 137 | 2001 |
Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses AJ Oakley, S Barrett, TS Peat, J Newman, VA Streltsov, L Waddington, ... American Chemical Society, 2010 | 118 | 2010 |
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes J Moeker, TS Peat, LF Bornaghi, D Vullo, CT Supuran, SA Poulsen Journal of medicinal chemistry 57 (8), 3522-3531, 2014 | 115 | 2014 |
Class‐directed structure determination: Foundation for a protein structure initiative TC Terwilliger, G Waldo, TS Peat, JM Newman, KC And, J Berendzen Protein Science 7 (9), 1851-1856, 1998 | 115 | 1998 |
Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site RP Tanpure, B Ren, TS Peat, LF Bornaghi, D Vullo, CT Supuran, ... Journal of medicinal chemistry 58 (3), 1494-1501, 2015 | 108 | 2015 |
Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst AC Warden, M Williams, TS Peat, SA Seabrook, J Newman, G Dojchinov, ... Nature Communications 6 (1), 10278, 2015 | 102 | 2015 |
Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis TS Peat, C Böttcher, J Newman, D Lucent, N Cowieson, C Davies The Plant Cell 24 (11), 4525-4538, 2012 | 93 | 2012 |
Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Wielens, SJ Headey, DI Rhodes, RJ Mulder, O Dolezal, JJ Deadman, ... Journal of Biomolecular Screening 18 (2), 147-159, 2013 | 85 | 2013 |
A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract N Wu, Y Zhu, S Brown, J Oakeshott, TS Peat, R Surjadi, C Easton, ... Lab on a Chip 9 (23), 3391-3398, 2009 | 77 | 2009 |
Discovery of new selenoureido analogues of 4-(4-fluorophenylureido) benzenesulfonamide as carbonic anhydrase inhibitors A Angeli, D Tanini, TS Peat, L Di Cesare Mannelli, G Bartolucci, ... ACS medicinal chemistry letters 8 (9), 963-968, 2017 | 67 | 2017 |
Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design TS Peat, DI Rhodes, N Vandegraaff, G Le, JA Smith, LJ Clark, ED Jones, ... PloS one 7 (7), e40147, 2012 | 63 | 2012 |
Native state mass spectrometry, surface plasmon resonance, and X-ray crystallography correlate strongly as a fragment screening combination LA Woods, O Dolezal, B Ren, JH Ryan, TS Peat, SA Poulsen Journal of Medicinal Chemistry 59 (5), 2192-2204, 2016 | 62 | 2016 |