Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens BM Hover, SH Kim, M Katz, Z Charlop-Powers, JG Owen, MA Ternei, ... Nature microbiology 3 (4), 415-422, 2018 | 461 | 2018 |
Secondary metabolism in the lichen symbiosis MJ Calcott, DF Ackerley, A Knight, RA Keyzers, JG Owen Chemical Society Reviews 47 (5), 1730-1760, 2018 | 243 | 2018 |
Global biogeographic sampling of bacterial secondary metabolism Z Charlop-Powers, JG Owen, BVB Reddy, MA Ternei, DO Guimarães, ... Elife 4, e05048, 2015 | 163 | 2015 |
Chemical-biogeographic survey of secondary metabolism in soil Z Charlop-Powers, JG Owen, BVB Reddy, MA Ternei, SF Brady Proceedings of the National Academy of Sciences 111 (10), 3757-3762, 2014 | 159 | 2014 |
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products JG Owen, BVB Reddy, MA Ternei, Z Charlop-Powers, PY Calle, JH Kim, ... Proceedings of the National Academy of Sciences 110 (29), 11797-11802, 2013 | 155 | 2013 |
Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective L Donald, A Pipite, R Subramani, J Owen, RA Keyzers, T Taufa Microbiology Research 13 (3), 418-465, 2022 | 151 | 2022 |
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors JG Owen, Z Charlop-Powers, AG Smith, MA Ternei, PY Calle, BVB Reddy, ... Proceedings of the National Academy of Sciences 112 (14), 4221-4226, 2015 | 131 | 2015 |
Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines AS Brown, MJ Calcott, JG Owen, DF Ackerley Natural product reports 35 (11), 1210-1228, 2018 | 94 | 2018 |
Efficient rational modification of non-ribosomal peptides by adenylation domain substitution MJ Calcott, JG Owen, DF Ackerley Nature communications 11 (1), 4554, 2020 | 90 | 2020 |
Biosynthesis of novel Pyoverdines by domain substitution in a nonribosomal peptide synthetase of Pseudomonas aeruginosa MJ Calcott, JG Owen, IL Lamont, DF Ackerley Applied and environmental microbiology 80 (18), 5723-5731, 2014 | 89 | 2014 |
Characterization of pyoverdine and achromobactin in Pseudomonas syringae pv. phaseolicola 1448a JG Owen, DF Ackerley BMC microbiology 11, 1-16, 2011 | 82 | 2011 |
Structure, function, and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria T Velkov, A Gallardo-Godoy, JD Swarbrick, MAT Blaskovich, AG Elliott, ... Cell chemical biology 25 (4), 380-391. e5, 2018 | 74 | 2018 |
A functional screen for recovery of 4′‐phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries JG Owen, KJ Robins, NS Parachin, DF Ackerley Environmental microbiology 14 (5), 1198-1209, 2012 | 73 | 2012 |
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences V Libis, N Antonovsky, M Zhang, Z Shang, D Montiel, J Maniko, MA Ternei, ... Nature communications 10 (1), 3848, 2019 | 69 | 2019 |
Rapid and flexible biochemical assays for evaluating 4′-phosphopantetheinyl transferase activity JG Owen, JN Copp, DF Ackerley Biochemical Journal 436 (3), 709-717, 2011 | 67 | 2011 |
Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts MA Storey, SK Andreassend, J Bracegirdle, A Brown, RA Keyzers, ... MBio 11 (2), 10.1128/mbio. 02997-19, 2020 | 64 | 2020 |
Proteomics quantifies protein expression changes in a model cnidarian colonised by a thermally tolerant but suboptimal symbiont AE Sproles, CA Oakley, JL Matthews, L Peng, JG Owen, AR Grossman, ... The ISME Journal 13 (9), 2334-2345, 2019 | 61 | 2019 |
Marine invertebrate natural products that target microtubules JH Miller, JJ Field, A Kanakkanthara, JG Owen, AJ Singh, PT Northcote Journal of natural products 81 (3), 691-702, 2018 | 54 | 2018 |
Generating functional recombinant NRPS enzymes in the laboratory setting via peptidyl carrier protein engineering JG Owen, MJ Calcott, KJ Robins, DF Ackerley Cell chemical biology 23 (11), 1395-1406, 2016 | 45 | 2016 |
Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of … Z Charlop-Powers, JJ Banik, JG Owen, JW Craig, SF Brady ACS chemical biology 8 (1), 138-143, 2013 | 31 | 2013 |